A disintegrin and metalloprotease with thrombospondin type I motif 7: a new protease for connective tissue growth factor in hepatic progenitor/oval cell niche.
The American journal of pathology. 185(6):1552-63 [DOI] 10.1016/j.ajpath.2015.02.008. [PMID] 25843683.
Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells.
World journal of biological chemistry. 6(4):379-88 [DOI] 10.4331/wjbc.v6.i4.379. [PMID] 26629321.
MicroRNA signature in wound healing following excimer laser ablation: role of miR-133b on TGFβ1, CTGF, SMA, and COL1A1 expression levels in rabbit corneal fibroblasts.
Investigative ophthalmology & visual science. 54(10):6944-51 [DOI] 10.1167/iovs.13-12621. [PMID] 24065814.
CCN2/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(8):3365-79 [DOI] 10.1096/fj.11-200154. [PMID] 22611085.
Inhibition of Notch signaling affects hepatic oval cell response in rat model of 2AAF-PH.
Hepatic medicine : evidence and research. 3:89-98 [PMID] 21927552.
Insulin-like growth factor binding protein-3 is required for the regulation of rat oval cell proliferation and differentiation in the 2AAF/PHX model.
Hepatic medicine : evidence and research. 2010(2):13-32 [PMID] 21852899.
Method for the decellularization of intact rat liver.
Organogenesis. 6(2):134-6 [PMID] 20885860.
Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model.
Oncology research. 17(8):339-45 [PMID] 19544970.
Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.
Journal of hepatology. 51(1):77-92 [DOI] 10.1016/j.jhep.2009.02.022. [PMID] 19446912.
Combined Hepatocholangiocarcinomas in Rats Develop From Bone Marrow-Derived Liver Stem Cells in Rats
Journal of Hepatology. 48:S35-S36 [DOI] 10.1016/S0168-8278(08)60083-5.
View on: Publisher’s Site
Hepatocyte Growth Factor and Granulocyte-Colony Stimulating Factor Guide the Growth, Motility and Survival of Oval Cell-Derived Rat Liver Cancer Cell Lines
Higher Education Policy. 48:496A-497A
Stem Cell Therapy for Inherited Metabolic Disorders of the Liver
Experimental Hematology. 36:716-725 [DOI] 10.1016/i.exphem.2008.02.002.
View on: Publisher’s Site
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
Gastroenterology. 132(3):1077-87 [PMID] 17383429.
Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats.
Gastroenterology. 133(2):619-31 [PMID] 17681181.
Microarray RNA/DNA in different stem cell lines.
Current pharmaceutical biotechnology. 8(3):167-75 [PMID] 17584089.
Stem cells, cancer, liver, and liver cancer stem cells: finding a way out of the labyrinth…
Current cancer drug targets. 7(6):582-90 [PMID] 17896923.
A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells.
Laboratory investigation; a journal of technical methods and pathology. 86(5):477-89 [PMID] 16534498.
Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 54(9):1051-9 [PMID] 16709727.
Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation.
Stem cells (Dayton, Ohio). 24(4):1054-64 [PMID] 16322639.
Oval cell response in 2-acetylaminofluorene/partial hepatectomy rat is attenuated by short interfering RNA targeted to stromal cell-derived factor-1.
The American journal of pathology. 169(6):2066-74 [PMID] 17148669.
Evidence regarding a stem cell origin of hepatocellular carcinoma.
Stem cell reviews. 1(3):261-4 [PMID] 17142863.
Monocrotaline, an alternative to retrorsine-based hepatocyte transplantation in rodents.
Cell transplantation. 14(1):41-7 [PMID] 15789661.
Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats.
Gastroenterology. 128(7):2077-88 [PMID] 15940639.
Stem-cell therapy for hepatobiliary pancreatic disease.
Journal of hepato-biliary-pancreatic surgery. 12(3):190-5 [PMID] 15995806.
Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells.
The American journal of pathology. 166(6):1781-91 [PMID] 15920163.
Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes.
Laboratory investigation; a journal of technical methods and pathology. 84(5):607-17 [PMID] 15034596.
Signalling in stem cells: meeting on signal transduction determining the fate of stem cells.
EMBO reports. 5(3):241-4 [PMID] 14978509.
An overview of stem cell research and regulatory issues.
Mayo Clinic proceedings. 78(8):993-1003 [PMID] 12911047.
ATP binding cassette transporter gene expression in rat liver progenitor cells.
Gut. 52(7):1060-7 [PMID] 12801967.
Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers.
Hepatology (Baltimore, Md.). 37(3):632-40 [PMID] 12601361.
Neural trans-differentiation potential of hepatic oval cells in the neonatal mouse brain.
Experimental neurology. 182(2):373-82 [PMID] 12895448.
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Nature. 416(6880):542-5 [PMID] 11932747.
Hepatic oval ‘stem’ cell in liver regeneration.
Seminars in cell & developmental biology. 13(6):405-9 [PMID] 12468240.
Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury.
Journal of hematotherapy & stem cell research. 11(4):643-9 [PMID] 12201952.
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
Proceedings of the National Academy of Sciences of the United States of America. 99(12):8078-83 [PMID] 12048252.
SDF-1alpha/CXCR4: a mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats.
Cloning and stem cells. 4(4):339-51 [PMID] 12626097.
Hepatic “stem” cells: coming full circle.
Blood cells, molecules & diseases. 27(3):590-600 [PMID] 11482872.
Bone marrow as a potential source of hepatic oval cells.
Science (New York, N.Y.). 284(5417):1168-70 [PMID] 10325227.
Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat.
Cancer research. 59(16):3954-60 [PMID] 10463591.
Hepatocyte growth factor (HGF) and receptor (c-met) in normal and malignant astrocytic cells.
Anticancer research. 19(3A):1635-40 [PMID] 10470094.
Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats.
Hepatology (Baltimore, Md.). 27(4):1030-8 [PMID] 9537443.
Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat.
Hepatology (Baltimore, Md.). 27(2):433-45 [PMID] 9462642.
Bile ductular damage induced by methylene dianiline inhibits oval cell activation.
The American journal of pathology. 151(4):905-9 [PMID] 9327722.
Expression of HGF and cMet in the developing and adult brain.
Brain research. Developmental brain research. 102(2):299-303 [PMID] 9352114.
Extracellular matrix remodeling at the early stages of liver regeneration in the rat.
Hepatology (Baltimore, Md.). 26(4):896-904 [PMID] 9328311.
Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c-met receptor expression.
Stem cells (Dayton, Ohio). 14(5):592-602 [PMID] 8888500.
Sep 2018 – Aug 2021
The CTGF as a Therapeutic Target in Alcohol Liver Fibrosis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAAA
Jul 2012 – May 2016
Mechanisms of Oval Cell Activation and Differentiation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Issued August 2015
Delaying the Progression of Diabetes#9,109,042
Published October 2007
Astrocytic Lineage Generation from Bone Marrow Derived Stem Cells#US-2008-0138319-A1
Issued January 2007
Bone Marrow Cell Differentiation#7,169,608
Published August 2003
Neurogenesis from Hepatic Stem Cells#US-2004-0063202-A1
Published November 2001
Targeting Pluripotent Stem Cells to Tissues#US-2002-0094327-A1