Bryon E Petersen

Bryon E Petersen

Professor

Department: MD-CHILD HEALTH RES INSTITUTE
Business Phone: (352) 294-5680
Business Email: bryonpetersen@peds.ufl.edu

Publications

2017
Hepatic progenitor cell activation in liver repair.
Liver research. 1(2):81-87 [DOI] 10.1016/j.livres.2017.08.002. [PMID] 29276644.
2017
Suppression of islet homeostasis protein thwarts diabetes mellitus progression.
Laboratory investigation; a journal of technical methods and pathology. 97(5):577-590 [DOI] 10.1038/labinvest.2017.15. [PMID] 28218739.
2016
miR-133b Regulation of Connective Tissue Growth Factor: A Novel Mechanism in Liver Pathology.
The American journal of pathology. 186(5):1092-102 [DOI] 10.1016/j.ajpath.2015.12.022. [PMID] 26945106.
2015
A disintegrin and metalloprotease with thrombospondin type I motif 7: a new protease for connective tissue growth factor in hepatic progenitor/oval cell niche.
The American journal of pathology. 185(6):1552-63 [DOI] 10.1016/j.ajpath.2015.02.008. [PMID] 25843683.
2015
Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice.
Hepatology (Baltimore, Md.). 61(2):678-91 [DOI] 10.1002/hep.27425. [PMID] 25203810.
2015
Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells.
World journal of biological chemistry. 6(4):379-88 [DOI] 10.4331/wjbc.v6.i4.379. [PMID] 26629321.
2015
Liver regeneration: A consequence of complex, well-orchestrated signals.
Hepatology (Baltimore, Md.). 62(2):644-5 [DOI] 10.1002/hep.27883. [PMID] 25953495.
2015
PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation.
The American journal of pathology. 185(5):1396-408 [DOI] 10.1016/j.ajpath.2015.01.018. [PMID] 25773177.
2014
Conditional knockout of CTGF affects corneal wound healing.
Investigative ophthalmology & visual science. 55(4):2062-70 [DOI] 10.1167/iovs.13-12735. [PMID] 24627144.
2013
Immunogenicity of decellularized porcine liver for bioengineered hepatic tissue.
The American journal of pathology. 183(2):558-65 [DOI] 10.1016/j.ajpath.2013.05.002. [PMID] 23747949.
2013
MicroRNA signature in wound healing following excimer laser ablation: role of miR-133b on TGFβ1, CTGF, SMA, and COL1A1 expression levels in rabbit corneal fibroblasts.
Investigative ophthalmology & visual science. 54(10):6944-51 [DOI] 10.1167/iovs.13-12621. [PMID] 24065814.
2012
Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.
Liver international : official journal of the International Association for the Study of the Liver. 32(2):312-20 [DOI] 10.1111/j.1478-3231.2011.02642.x. [PMID] 22098068.
2012
CCN2/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(8):3365-79 [DOI] 10.1096/fj.11-200154. [PMID] 22611085.
2012
Characterization of a novel functional protein in the pancreatic islet: islet homeostasis protein regulation of glucagon synthesis in α cells.
Pancreas. 41(1):22-30 [DOI] 10.1097/MPA.0b013e3182222ee5. [PMID] 22143342.
2011
Adipose tissue-derived mesenchymal stem cell-based liver gene delivery.
Journal of hepatology. 54(5):930-8 [DOI] 10.1016/j.jhep.2010.07.051. [PMID] 21168381.
2011
Inhibition of Notch signaling affects hepatic oval cell response in rat model of 2AAF-PH.
Hepatic medicine : evidence and research. 3:89-98 [PMID] 21927552.
View on: PubMed
2011
Potential applications for cell regulatory factors in liver progenitor cell therapy.
The international journal of biochemistry & cell biology. 43(2):214-21 [DOI] 10.1016/j.biocel.2010.09.005. [PMID] 20851776.
2010
The role of the Wnt family of secreted proteins in rat oval “stem” cell-based liver regeneration: Wnt1 drives differentiation.
The American journal of pathology. 176(6):2732-42 [DOI] 10.2353/ajpath.2010.080486. [PMID] 20413689.
2010
Method for the decellularization of intact rat liver.
Organogenesis. 6(2):134-6 [PMID] 20885860.
View on: PubMed
2010
Insulin-like growth factor binding protein-3 is required for the regulation of rat oval cell proliferation and differentiation in the 2AAF/PHX model.
Hepatic medicine : evidence and research. 2010(2):13-32 [PMID] 21852899.
View on: PubMed
2010
Hepatic stellate cells’ involvement in progenitor-mediated liver regeneration.
Laboratory investigation; a journal of technical methods and pathology. 90(8):1199-208 [DOI] 10.1038/labinvest.2010.88. [PMID] 20440274.
2010
Biology of the adult hepatic progenitor cell: “ghosts in the machine”.
Progress in molecular biology and translational science. 97:229-49 [DOI] 10.1016/B978-0-12-385233-5.00008-8. [PMID] 21074735.
2010
Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy. 18(8):1553-8 [DOI] 10.1038/mt.2010.116. [PMID] 20551917.
2009
A detailed characterization of the adult mouse model of glycogen storage disease Ia.
Laboratory investigation; a journal of technical methods and pathology. 89(9):1032-42 [DOI] 10.1038/labinvest.2009.64. [PMID] 19581879.
2009
Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model.
Oncology research. 17(8):339-45 [PMID] 19544970.
View on: PubMed
2009
Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model.
Oncology research. 17(8) [DOI] 10.3727/096504009788428424. [PMID] 19544970.
2009
Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism.
Stem cells and development. 18(1):37-46 [DOI] 10.1089/scd.2007.0255. [PMID] 18393672.
2009
Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.
Journal of hepatology. 51(1):77-92 [DOI] 10.1016/j.jhep.2009.02.022. [PMID] 19446912.
2009
Isolation and characterization of hepatic stem cells, or “oval cells,” from rat livers.
Methods in molecular biology (Clifton, N.J.). 482:387-405 [DOI] 10.1007/978-1-59745-060-7_24. [PMID] 19089369.
2008
Combined Hepatocholangiocarcinomas in Rats Develop From Bone Marrow-Derived Liver Stem Cells in Rats
. 48:S35-S36 [DOI] 10.1016/S0168-8278(08)60083-5.
2008
Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation.
Hepatology (Baltimore, Md.). 47(3):996-1004 [DOI] 10.1002/hep.22079. [PMID] 18167060.
2008
Hepatocyte Growth Factor and Granulocyte-Colony Stimulating Factor Guide the Growth, Motility and Survival of Oval Cell-Derived Rat Liver Cancer Cell Lines
Higher Education Policy. 48:496A-497A
2008
Location Is Everything: the Liver Stem Cell Niche
Higher Education Policy. 47(6):1810-1812 [DOI] 10.1002/hep.22333. [PMID] 18506878.
2008
Stem Cell Therapy for Inherited Metabolic Disorders of the Liver
Experimental Hematology. 36:716-725 [DOI] 10.1016/i.exphem.2008.02.002.
2008
Stem cell therapy for inherited metabolic disorders of the liver.
Experimental hematology. 36(6):716-725 [DOI] 10.1016/j.exphem.2008.02.002. [PMID] 18375039.
2008
Thy1-positive bone marrow stem cells express liver-specific genes in vitro and can mature into hepatocytes in vivo.
Hepatology international. 2(1):63-71 [DOI] 10.1007/s12072-007-9031-4. [PMID] 19669280.
2007
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
Gastroenterology. 132(3):1077-87 [PMID] 17383429.
View on: PubMed
2007
Microarray RNA/DNA in different stem cell lines.
Current pharmaceutical biotechnology. 8(3):167-75 [PMID] 17584089.
View on: PubMed
2007
Stem cells, cancer, liver, and liver cancer stem cells: finding a way out of the labyrinth…
Current cancer drug targets. 7(6):582-90 [PMID] 17896923.
View on: PubMed
2007
Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats.
Gastroenterology. 133(2):619-31 [PMID] 17681181.
View on: PubMed
2006
A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells.
Laboratory investigation; a journal of technical methods and pathology. 86(5):477-89 [PMID] 16534498.
View on: PubMed
2006
Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 54(9):1051-9 [PMID] 16709727.
View on: PubMed
2006
Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation.
Stem cells (Dayton, Ohio). 24(4):1054-64 [PMID] 16322639.
View on: PubMed
2006
Oval cell response in 2-acetylaminofluorene/partial hepatectomy rat is attenuated by short interfering RNA targeted to stromal cell-derived factor-1.
The American journal of pathology. 169(6):2066-74 [PMID] 17148669.
View on: PubMed
2005
Evidence regarding a stem cell origin of hepatocellular carcinoma.
Stem cell reviews. 1(3):261-4 [PMID] 17142863.
View on: PubMed
2005
Monocrotaline, an alternative to retrorsine-based hepatocyte transplantation in rodents.
Cell transplantation. 14(1):41-7 [PMID] 15789661.
View on: PubMed
2005
Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats.
Gastroenterology. 128(7):2077-88 [PMID] 15940639.
View on: PubMed
2005
Stem-cell therapy for hepatobiliary pancreatic disease.
Journal of hepato-biliary-pancreatic surgery. 12(3):190-5 [PMID] 15995806.
View on: PubMed
2005
Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells.
The American journal of pathology. 166(6):1781-91 [PMID] 15920163.
View on: PubMed
2004
Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes.
Laboratory investigation; a journal of technical methods and pathology. 84(5):607-17 [PMID] 15034596.
View on: PubMed
2004
Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice.
Hepatology (Baltimore, Md.). 40(4):918-24 [PMID] 15382177.
View on: PubMed
2004
Signalling in stem cells: meeting on signal transduction determining the fate of stem cells.
EMBO reports. 5(3):241-4 [PMID] 14978509.
View on: PubMed
2003
Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers.
Hepatology (Baltimore, Md.). 37(3):632-40 [PMID] 12601361.
View on: PubMed
2003
Neural trans-differentiation potential of hepatic oval cells in the neonatal mouse brain.
Experimental neurology. 182(2):373-82 [PMID] 12895448.
View on: PubMed
2003
An overview of stem cell research and regulatory issues.
Mayo Clinic proceedings. 78(8):993-1003 [PMID] 12911047.
View on: PubMed
2003
ATP binding cassette transporter gene expression in rat liver progenitor cells.
Gut. 52(7):1060-7 [PMID] 12801967.
View on: PubMed
2002
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Nature. 416(6880):542-5 [PMID] 11932747.
View on: PubMed
2002
Hepatic oval ‘stem’ cell in liver regeneration.
Seminars in cell & developmental biology. 13(6):405-9 [PMID] 12468240.
View on: PubMed
2002
Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury.
Journal of hematotherapy & stem cell research. 11(4):643-9 [PMID] 12201952.
View on: PubMed
2002
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
Proceedings of the National Academy of Sciences of the United States of America. 99(12):8078-83 [PMID] 12048252.
View on: PubMed
2002
SDF-1alpha/CXCR4: a mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats.
Cloning and stem cells. 4(4):339-51 [PMID] 12626097.
View on: PubMed
2001
Hepatic “stem” cells: coming full circle.
Blood cells, molecules & diseases. 27(3):590-600 [PMID] 11482872.
View on: PubMed
2001
Stem cells: a journey into a new frontier.
Journal of the American Society of Nephrology : JASN. 12(8):1773-80 [PMID] 11461953.
View on: PubMed
1999
Hepatocyte growth factor (HGF) and receptor (c-met) in normal and malignant astrocytic cells.
Anticancer research. 19(3A):1635-40 [PMID] 10470094.
View on: PubMed
1999
Bone marrow as a potential source of hepatic oval cells.
Science (New York, N.Y.). 284(5417):1168-70 [PMID] 10325227.
View on: PubMed
1999
Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat.
Cancer research. 59(16):3954-60 [PMID] 10463591.
View on: PubMed
1998
Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats.
Hepatology (Baltimore, Md.). 27(4):1030-8 [PMID] 9537443.
View on: PubMed
1998
Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat.
Hepatology (Baltimore, Md.). 27(2):433-45 [PMID] 9462642.
View on: PubMed
1997
Bile ductular damage induced by methylene dianiline inhibits oval cell activation.
The American journal of pathology. 151(4):905-9 [PMID] 9327722.
View on: PubMed
1997
Expression of HGF and cMet in the developing and adult brain.
Brain research. Developmental brain research. 102(2):299-303 [PMID] 9352114.
View on: PubMed
1997
Extracellular matrix remodeling at the early stages of liver regeneration in the rat.
Hepatology (Baltimore, Md.). 26(4):896-904 [PMID] 9328311.
View on: PubMed
1996
Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c-met receptor expression.
Stem cells (Dayton, Ohio). 14(5):592-602 [PMID] 8888500.
View on: PubMed

Grants

Sep 2018 ACTIVE
The CTGF as a Therapeutic Target in Alcohol Liver Fibrosis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAAA
Jul 2012 – May 2016
Mechanisms of Oval Cell Activation and Differentiation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Patents

Published November 2001
Targeting Pluripotent Stem Cells to Tissues
#US-2002-0094327-A1
Published August 2003
Neurogenesis from Hepatic Stem Cells
#US-2004-0063202-A1
Issued January 2007
Bone Marrow Cell Differentiation
#7,169,608
Published October 2007
Astrocytic Lineage Generation from Bone Marrow Derived Stem Cells
#US-2008-0138319-A1
Issued August 2015
Delaying the Progression of Diabetes
#9,109,042

Contact Details

Phones:
Business:
(352) 294-5680
Emails: