Jason Coleman, Ph.D.

Jason ColemanDivision

Child Health Research Institute

Academic Title

Assistant Professor

Contact Information



Coleman VisualTraining

  • Postdoctoral Training, Massachusetts Institute of Technology (MIT)
  • Ph.D., University of Florida (UF)
  • B.S., University of Florida


Dr. Coleman performed his doctoral research in the laboratory of Dr. Sue Semple-Rowland in the Department of Neuroscience at UF.  He continued his training as a Howard Hughes Medical Institute postdoctoral fellow in the Picower Institute for Learning and Memory at MIT with Dr. Mark Bear. Dr. Coleman was recently awarded a grant from the National Institute of Neurological Disorders and Stroke at NIH. He also serves as a co-investigator on grants from the NIH and NSF.

Research Overview

My interests lie in understanding how experience modifies the structure and function of neural circuitry in the cerebral cortex, which is crucial for many high-level brain functions including sensation, perception, learning and memory, and behavioral control.  During early development, synaptic connectivity in the cortex is guided by molecular and experiential cues and is extremely vulnerable to perinatal insults such as the mis-expression of proteins, sensory impairment, and intrauterine stress.  Even relatively minor alterations to the wiring scheme in cortex can have a major impact on long-term cognitive function.  Thus, I am also interested in understanding how perturbations during early development impact the long-term structure and function of specific cortical circuits.

In the pursuit of these interests, my laboratory uses a multi-faceted approach that combines behavioral, molecular, neurophysiological, and optically based approaches for monitoring the structure and function of specific neural circuits.  Part of our efforts are also aimed at developing and implementing novel tools for labeling and monitoring populations of neural cells and their fine structure in vivo.

Key Publications

Additional publications can be found in PubMed.

  1. Liu CH, Coleman JE, Davoudi H, Zhang K, and Shuler MGH (2015). Selective activation of a putative reinforcement signal conditions cued interval timing in primary visual cortex. Curr. Biology, doi: 10.1016/j.cub.2015.04.028. (PMID: 26004763).
  2. Coleman JE, Heynen AJ, and Bear MF (2013). The Molecular and Structural Basis of Amblyopia. {p. 1433) The New Visual Neurosciences. Ed. Werner JS and Chalupa LM. Cambridge, MA. MIT Press.
  3. Coleman JE, Nahmani M, Gavornik JP, Haslinger RH, Heynen AJ, Erisir A  and Bear MF and (2010) Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex. J. Neurosci. 30, 9670-9682.
  4. Coleman JE, Law K and Bear MF (2009). Anatomical origins of ocular dominance in mouse primary visual cortex. Neuroscience. 161(2), 561-571.
  5. Williams ME*, Coleman JE*, Haire S, Aleman T, Cideciyan A, Sokal I, Palczewski K, Jacobson SG and Semple-Rowland SL (2006). Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Medicine. 3(6), e201 doi:10.1371/journal.pmed.0030201 *Equal contribution by authors
  6. Coleman JE, Huentelman MJ*, Kasparov S, Metcalfe BL, Paton JFR, Katovich MJ, Semple-Rowland SL and Raizada MK (2003). Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol. Genomics. 12, 221-228.