Huanzhou Xu, Ph.D.
Assistant Scientist
Department:
MD-PEDS-INFECTIOUS DISEASES
Business Phone:
(352) 294-8854
Business Email:
huanzhou.xu@ufl.edu
About Huanzhou Xu
I focus on identifying novel cellular proteins on DNA replication forks and determining how these and other cell proteins change the composition of the machinery that replicates cell DNA, a critical function of cancer development and progress.
Publications
Academic Articles
2025
Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein–Barr virus in diffuse large B-cell lymphomas
NAR Cancer.
7(2)
[DOI] 10.1093/narcan/zcaf017.
[PMID] 40330549.
2025
STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas.
PLoS pathogens.
21(5)
[DOI] 10.1371/journal.ppat.1013166.
[PMID] 40354417.
2024
Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas.
Journal of virology.
98(7)
[DOI] 10.1128/jvi.00572-24.
[PMID] 38860782.
2023
ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication.
Nucleic acids research.
51(20):11104-11122
[DOI] 10.1093/nar/gkad823.
[PMID] 37852757.
2022
DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks
Clinical Cancer Research.
28(4):756-769
[DOI] 10.1158/1078-0432.ccr-21-2863.
2022
IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency.
Journal of virology.
96(17)
[DOI] 10.1128/jvi.01028-22.
[PMID] 35969079.
2022
SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway.
Virology.
568:13-22
[DOI] 10.1016/j.virol.2022.01.003.
[PMID] 35066302.
2022
Systematic Investigations on the Metabolic and Transcriptomic Regulation of Lactate in the Human Colon Epithelial Cells
International Journal of Molecular Sciences.
23(11)
[DOI] 10.3390/ijms23116262.
[PMID] 35682941.
2022
The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells.
Virology.
566:136-142
[DOI] 10.1016/j.virol.2021.12.002.
[PMID] 34922257.
2021
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication.
Blood.
138(26):2838-2852
[DOI] 10.1182/blood.2021011707.
[PMID] 34255814.
2021
A heterochromatin inducing protein differentially recognizes self versus foreign genomes.
PLoS pathogens.
17(3)
[DOI] 10.1371/journal.ppat.1009447.
[PMID] 33730092.
2021
Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency.
Journal of virology.
95(13)
[DOI] 10.1128/JVI.02466-20.
[PMID] 33853959.
2019
Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes.
PLoS pathogens.
15(12)
[DOI] 10.1371/journal.ppat.1008228.
[PMID] 31841561.
2018
The 5′ Untranslated Region of Human Bocavirus Capsid Transcripts Regulates Viral mRNA Biogenesis and Alternative Translation.
Journal of virology.
92(21)
[DOI] 10.1128/JVI.00443-18.
[PMID] 30111560.
2017
Alternative Polyadenylation of Human Bocavirus at Its 3′ End Is Regulated by Multiple Elements and Affects Capsid Expression.
Journal of virology.
91(3)
[DOI] 10.1128/JVI.02026-16.
[PMID] 27881651.
2017
The formation and modification of chromatin-like structure of human parvovirus B19 regulate viral genome replication and RNA processing.
Virus research.
232:134-138
[DOI] 10.1016/j.virusres.2017.03.001.
[PMID] 28263841.
2015
A multiplex PCR assay for the detection of five influenza viruses using a dual priming oligonucleotide system.
BMC infectious diseases.
15
[DOI] 10.1186/s12879-015-0818-y.
[PMID] 25886516.
Contact Details
Phones:
- Business:
- (352) 294-8854
Emails:
- Business:
- huanzhou.xu@ufl.edu
Addresses:
- Business Mailing:
-
ACADEMIC RESEARCH BUILDING, R1 175 1600 SW A
GAINESVILLE FL 326100001 - Business Street:
-
ACADEMIC RESEARCH BUILDING, R1 175 1600 SW A
GAINESVILLE FL 326100001