Huanzhou Xu

Huanzhou Xu, Ph.D.

Assistant Scientist

Department: MD-PEDS-INFECTIOUS DISEASES
Business Phone: (352) 294-8854
Business Email: huanzhou.xu@ufl.edu

About Huanzhou Xu

I focus on identifying novel cellular proteins on DNA replication forks and determining how these and other cell proteins change the composition of the machinery that replicates cell DNA, a critical function of cancer development and progress.

Publications

Academic Articles
2025
Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein–Barr virus in diffuse large B-cell lymphomas
NAR Cancer. 7(2) [DOI] 10.1093/narcan/zcaf017. [PMID] 40330549.
2025
STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas.
PLoS pathogens. 21(5) [DOI] 10.1371/journal.ppat.1013166. [PMID] 40354417.
2024
Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas.
Journal of virology. 98(7) [DOI] 10.1128/jvi.00572-24. [PMID] 38860782.
2023
ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication.
Nucleic acids research. 51(20):11104-11122 [DOI] 10.1093/nar/gkad823. [PMID] 37852757.
2022
DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks
Clinical Cancer Research. 28(4):756-769 [DOI] 10.1158/1078-0432.ccr-21-2863.
2022
IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency.
Journal of virology. 96(17) [DOI] 10.1128/jvi.01028-22. [PMID] 35969079.
2022
SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway.
Virology. 568:13-22 [DOI] 10.1016/j.virol.2022.01.003. [PMID] 35066302.
2022
Systematic Investigations on the Metabolic and Transcriptomic Regulation of Lactate in the Human Colon Epithelial Cells
International Journal of Molecular Sciences. 23(11) [DOI] 10.3390/ijms23116262. [PMID] 35682941.
2022
The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells.
Virology. 566:136-142 [DOI] 10.1016/j.virol.2021.12.002. [PMID] 34922257.
2021
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication.
Blood. 138(26):2838-2852 [DOI] 10.1182/blood.2021011707. [PMID] 34255814.
2021
A heterochromatin inducing protein differentially recognizes self versus foreign genomes.
PLoS pathogens. 17(3) [DOI] 10.1371/journal.ppat.1009447. [PMID] 33730092.
2021
Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency.
Journal of virology. 95(13) [DOI] 10.1128/JVI.02466-20. [PMID] 33853959.
2019
Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes.
PLoS pathogens. 15(12) [DOI] 10.1371/journal.ppat.1008228. [PMID] 31841561.
2018
The 5′ Untranslated Region of Human Bocavirus Capsid Transcripts Regulates Viral mRNA Biogenesis and Alternative Translation.
Journal of virology. 92(21) [DOI] 10.1128/JVI.00443-18. [PMID] 30111560.
2017
Alternative Polyadenylation of Human Bocavirus at Its 3′ End Is Regulated by Multiple Elements and Affects Capsid Expression.
Journal of virology. 91(3) [DOI] 10.1128/JVI.02026-16. [PMID] 27881651.
2017
The formation and modification of chromatin-like structure of human parvovirus B19 regulate viral genome replication and RNA processing.
Virus research. 232:134-138 [DOI] 10.1016/j.virusres.2017.03.001. [PMID] 28263841.
2015
A multiplex PCR assay for the detection of five influenza viruses using a dual priming oligonucleotide system.
BMC infectious diseases. 15 [DOI] 10.1186/s12879-015-0818-y. [PMID] 25886516.

Contact Details

Phones:
Business:
(352) 294-8854
Emails:
Addresses:
Business Mailing:
ACADEMIC RESEARCH BUILDING, R1 175 1600 SW A
GAINESVILLE FL 326100001
Business Street:
ACADEMIC RESEARCH BUILDING, R1 175 1600 SW A
GAINESVILLE FL 326100001