Christopher C Wendler

Christopher C Wendler, Ph.D.

Assistant Professor

Department: MD-CHILD HEALTH RES INSTITUTE
Business Phone: (352) 294-4451
Business Email: cwendler@ufl.edu

Publications

2021
Knockdown of DNA methyltransferase 1 reduces DNA methylation and alters expression patterns of cardiac genes in embryonic cardiomyocytes.
FEBS open bio. [DOI] 10.1002/2211-5463.13252. [PMID] 34235895.
2017
Long-term consequences of disrupting adenosine signaling during embryonic development.
Molecular aspects of medicine. 55:110-117 [DOI] 10.1016/j.mam.2017.02.001. [PMID] 28202385.
2017
Opposing Effects of Maternal Hypo- and Hyperthyroidism on the Stability of Thalamocortical Synapses in the Visual Cortex of Adult Offspring.
Cerebral cortex (New York, N.Y. : 1991). 27(5):3015-3027 [DOI] 10.1093/cercor/bhw096. [PMID] 27235101.
2016
In Utero Caffeine Exposure Induces Transgenerational Effects on the Adult Heart.
Scientific reports. 6 [DOI] 10.1038/srep34106. [PMID] 27677355.
2016
Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(9):3238-55 [DOI] 10.1096/fj.201600346R. [PMID] 27306334.
2015
cAMP induces hypertrophy and alters DNA methylation in HL-1 cardiomyocytes.
American journal of physiology. Cell physiology. 309(6):C425-36 [DOI] 10.1152/ajpcell.00058.2015. [PMID] 26224577.
2014
Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes.
American journal of physiology. Regulatory, integrative and comparative physiology. 307(12):R1471-87 [DOI] 10.1152/ajpregu.00307.2014. [PMID] 25354728.
2014
CHRONIC NEONATAL DIAZOXIDE THERAPY IS NOT ASSOCIATED WITH ADVERSE EFFECTS.
OnLine journal of biological sciences. 14(1):49-56 [PMID] 25587244.
View on: PubMed
2014
Diazoxide promotes oligodendrocyte differentiation in neonatal brain in normoxia and chronic sublethal hypoxia.
Brain research. 1586:64-72 [DOI] 10.1016/j.brainres.2014.08.046. [PMID] 25157906.
2014
Embryonic caffeine exposure acts via A1 adenosine receptors to alter adult cardiac function and DNA methylation in mice.
PloS one. 9(1) [DOI] 10.1371/journal.pone.0087547. [PMID] 24475304.
2014
Evaluation of developmental toxicity of propylthiouracil and methimazole.
Birth defects research. Part B, Developmental and reproductive toxicology. 101(4):300-7 [DOI] 10.1002/bdrb.21113. [PMID] 24980470.
2013
Embryonic exposure to propylthiouracil disrupts left-right patterning in Xenopus embryos.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(2):684-91 [DOI] 10.1096/fj.12-218073. [PMID] 23150524.
2013
In Utero Caffeine Exposure Alters Dna Methylation Patterns and Gene Expression in Hearts
Birth Defects Research Part A-Clinical and Molecular Teratology. 97
2013
In Utero Caffeine Exposure Alters Dna Methylation Patterns and Gene Expression in Hearts
Birth Defects Research Part A-Clinical and Molecular Teratology. 97
2012
In Utero Caffeine Exposure Alters Dna Methylation Patterns in Adult Hearts
Birth Defects Research Part A-Clinical and Molecular Teratology. 94
2012
Neurodevelopmental Effects of in Utero Exposure To Antithyroid Drugs in Mice
Birth Defects Research Part A-Clinical and Molecular Teratology. 94
2012
Propylthiouracil is teratogenic in murine embryos.
PloS one. 7(4) [DOI] 10.1371/journal.pone.0035213. [PMID] 22529993.
2012
Regulation of cardiovascular development by adenosine and adenosine-mediated embryo protection.
Arteriosclerosis, thrombosis, and vascular biology. 32(4):851-5 [DOI] 10.1161/ATVBAHA.111.226811. [PMID] 22423036.
2011
Adverse and protective influences of adenosine on the newborn and embryo: implications for preterm white matter injury and embryo protection.
Pediatric research. 69(4):271-8 [DOI] 10.1203/PDR.0b013e31820efbcf. [PMID] 21228731.
2011
Caffeine acts via A1 adenosine receptors to disrupt embryonic cardiac function.
PloS one. 6(12) [DOI] 10.1371/journal.pone.0028296. [PMID] 22164264.
2011
The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development.
BMC developmental biology. 11 [DOI] 10.1186/1471-213X-11-37. [PMID] 21668976.
2010
Identification of the heart as the critical site of adenosine mediated embryo protection.
BMC developmental biology. 10 [DOI] 10.1186/1471-213X-10-57. [PMID] 20509906.
2009
Embryonic caffeine exposure induces adverse effects in adulthood.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(4):1272-8 [DOI] 10.1096/fj.08-124941. [PMID] 19088180.
2008
Hypoxia induces cardiac malformations via A1 adenosine receptor activation in chicken embryos.
Birth defects research. Part A, Clinical and molecular teratology. 82(3):121-30 [DOI] 10.1002/bdra.20438. [PMID] 18186126.
2007
A1 adenosine receptors play an essential role in protecting the embryo against hypoxia.
Proceedings of the National Academy of Sciences of the United States of America. 104(23):9697-702 [PMID] 17522253.
View on: PubMed
2006
Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development.
Developmental biology. 291(2):264-77 [PMID] 16434032.
View on: PubMed
2003
Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice.
Circulation research. 92(8):920-8 [PMID] 12663486.
View on: PubMed
1999
Utilization of antisense oligodeoxynucleotides with embryonic tissues in culture.
Methods (San Diego, Calif.). 18(3):316-21 [PMID] 10454991.
View on: PubMed

Grants

Jun 2020 ACTIVE
STTR Phase 2 – Prevention of White Matter Injury in Premature Infants
Role: Co-Investigator
Funding: MEDOSOME BIOTEC via NATL INST OF HLTH NICHD
Sep 2019 – Aug 2021
STTR – Development of a Novel Therapeutic for Hyperthyroidism
Role: Co-Investigator
Funding: MEDOSOME BIOTEC via NATL INST OF HLTH NIDDK
May 2019 – Apr 2020
Prevention of White Matter Injury in Premature Infants
Role: Co-Investigator
Funding: MEDOSOME BIOTEC via NATL INST OF HLTH NICHD

Teaching Profile

Courses Taught
2018
MDT7090 Elective Topics

Contact Details

Phones:
Business:
(352) 294-4451
Emails:
Business:
cwendler@ufl.edu