Bryon E Petersen,
Professor
Department:
MD-CHILD HEALTH RES INSTITUTE
Business Phone:
(352) 294-5680
Business Email:
bryonpetersen@peds.ufl.edu
Publications
2017
Hepatic progenitor cell activation in liver repair.
Liver research.
1(2):81-87
[DOI] 10.1016/j.livres.2017.08.002.
[PMID] 29276644.
2017
Suppression of islet homeostasis protein thwarts diabetes mellitus progression.
Laboratory investigation; a journal of technical methods and pathology.
97(5):577-590
[DOI] 10.1038/labinvest.2017.15.
[PMID] 28218739.
2016
miR-133b Regulation of Connective Tissue Growth Factor: A Novel Mechanism in Liver Pathology.
The American journal of pathology.
186(5):1092-102
[DOI] 10.1016/j.ajpath.2015.12.022.
[PMID] 26945106.
2015
A disintegrin and metalloprotease with thrombospondin type I motif 7: a new protease for connective tissue growth factor in hepatic progenitor/oval cell niche.
The American journal of pathology.
185(6):1552-63
[DOI] 10.1016/j.ajpath.2015.02.008.
[PMID] 25843683.
2015
Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice.
Hepatology (Baltimore, Md.).
61(2):678-91
[DOI] 10.1002/hep.27425.
[PMID] 25203810.
2015
Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells.
World journal of biological chemistry.
6(4):379-88
[DOI] 10.4331/wjbc.v6.i4.379.
[PMID] 26629321.
2015
Liver regeneration: A consequence of complex, well-orchestrated signals.
Hepatology (Baltimore, Md.).
62(2):644-5
[DOI] 10.1002/hep.27883.
[PMID] 25953495.
2015
PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation.
The American journal of pathology.
185(5):1396-408
[DOI] 10.1016/j.ajpath.2015.01.018.
[PMID] 25773177.
2014
Conditional knockout of CTGF affects corneal wound healing.
Investigative ophthalmology & visual science.
55(4):2062-70
[DOI] 10.1167/iovs.13-12735.
[PMID] 24627144.
2013
Immunogenicity of decellularized porcine liver for bioengineered hepatic tissue.
The American journal of pathology.
183(2):558-65
[DOI] 10.1016/j.ajpath.2013.05.002.
[PMID] 23747949.
2013
MicroRNA signature in wound healing following excimer laser ablation: role of miR-133b on TGFβ1, CTGF, SMA, and COL1A1 expression levels in rabbit corneal fibroblasts.
Investigative ophthalmology & visual science.
54(10):6944-51
[DOI] 10.1167/iovs.13-12621.
[PMID] 24065814.
2012
CCN2/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
26(8):3365-79
[DOI] 10.1096/fj.11-200154.
[PMID] 22611085.
2012
Characterization of a novel functional protein in the pancreatic islet: islet homeostasis protein regulation of glucagon synthesis in α cells.
Pancreas.
41(1):22-30
[DOI] 10.1097/MPA.0b013e3182222ee5.
[PMID] 22143342.
2012
Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.
Liver international : official journal of the International Association for the Study of the Liver.
32(2):312-20
[DOI] 10.1111/j.1478-3231.2011.02642.x.
[PMID] 22098068.
2011
Adipose tissue-derived mesenchymal stem cell-based liver gene delivery.
Journal of hepatology.
54(5):930-8
[DOI] 10.1016/j.jhep.2010.07.051.
[PMID] 21168381.
2011
Inhibition of Notch signaling affects hepatic oval cell response in rat model of 2AAF-PH.
Hepatic medicine : evidence and research.
3:89-98
[PMID] 21927552.
2011
Potential applications for cell regulatory factors in liver progenitor cell therapy.
The international journal of biochemistry & cell biology.
43(2):214-21
[DOI] 10.1016/j.biocel.2010.09.005.
[PMID] 20851776.
2010
Biology of the adult hepatic progenitor cell: “ghosts in the machine”.
Progress in molecular biology and translational science.
97:229-49
[DOI] 10.1016/B978-0-12-385233-5.00008-8.
[PMID] 21074735.
2010
Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy.
18(8):1553-8
[DOI] 10.1038/mt.2010.116.
[PMID] 20551917.
2010
Hepatic stellate cells’ involvement in progenitor-mediated liver regeneration.
Laboratory investigation; a journal of technical methods and pathology.
90(8):1199-208
[DOI] 10.1038/labinvest.2010.88.
[PMID] 20440274.
2010
Insulin-like growth factor binding protein-3 is required for the regulation of rat oval cell proliferation and differentiation in the 2AAF/PHX model.
Hepatic medicine : evidence and research.
2010(2):13-32
[PMID] 21852899.
2010
Method for the decellularization of intact rat liver.
Organogenesis.
6(2):134-6
[PMID] 20885860.
2010
The role of the Wnt family of secreted proteins in rat oval “stem” cell-based liver regeneration: Wnt1 drives differentiation.
The American journal of pathology.
176(6):2732-42
[DOI] 10.2353/ajpath.2010.080486.
[PMID] 20413689.
2009
A detailed characterization of the adult mouse model of glycogen storage disease Ia.
Laboratory investigation; a journal of technical methods and pathology.
89(9):1032-42
[DOI] 10.1038/labinvest.2009.64.
[PMID] 19581879.
2009
Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model.
Oncology research.
17(8):339-45
[PMID] 19544970.
2009
Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism.
Stem cells and development.
18(1):37-46
[DOI] 10.1089/scd.2007.0255.
[PMID] 18393672.
2009
Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.
Journal of hepatology.
51(1):77-92
[DOI] 10.1016/j.jhep.2009.02.022.
[PMID] 19446912.
2009
Isolation and characterization of hepatic stem cells, or “oval cells,” from rat livers.
Methods in molecular biology (Clifton, N.J.).
482:387-405
[DOI] 10.1007/978-1-59745-060-7_24.
[PMID] 19089369.
2008
Combined Hepatocholangiocarcinomas in Rats Develop From Bone Marrow-Derived Liver Stem Cells in Rats
Journal of Hepatology.
48:S35-S36
[DOI] 10.1016/S0168-8278(08)60083-5.
2008
Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation.
Hepatology (Baltimore, Md.).
47(3):996-1004
[DOI] 10.1002/hep.22079.
[PMID] 18167060.
2008
Hepatocyte Growth Factor and Granulocyte-Colony Stimulating Factor Guide the Growth, Motility and Survival of Oval Cell-Derived Rat Liver Cancer Cell Lines
Higher Education Policy.
48:496A-497A
2008
Location Is Everything: the Liver Stem Cell Niche
Higher Education Policy.
47(6):1810-1812
[DOI] 10.1002/hep.22333.
[PMID] 18506878.
2008
Stem Cell Therapy for Inherited Metabolic Disorders of the Liver
Experimental Hematology.
36:716-725
[DOI] 10.1016/i.exphem.2008.02.002.
2008
Stem cell therapy for inherited metabolic disorders of the liver.
Experimental hematology.
36(6):716-725
[DOI] 10.1016/j.exphem.2008.02.002.
[PMID] 18375039.
2008
Thy1-positive bone marrow stem cells express liver-specific genes in vitro and can mature into hepatocytes in vivo.
Hepatology international.
2(1):63-71
[DOI] 10.1007/s12072-007-9031-4.
[PMID] 19669280.
2007
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
Gastroenterology.
132(3):1077-87
[PMID] 17383429.
2007
Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats.
Gastroenterology.
133(2):619-31
[PMID] 17681181.
2007
Microarray RNA/DNA in different stem cell lines.
Current pharmaceutical biotechnology.
8(3):167-75
[PMID] 17584089.
2007
Stem cells, cancer, liver, and liver cancer stem cells: finding a way out of the labyrinth..
Current cancer drug targets.
7(6):582-90
[PMID] 17896923.
2006
A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells.
Laboratory investigation; a journal of technical methods and pathology.
86(5):477-89
[PMID] 16534498.
2006
Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
54(9):1051-9
[PMID] 16709727.
2006
Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation.
Stem cells (Dayton, Ohio).
24(4):1054-64
[PMID] 16322639.
2006
Oval cell response in 2-acetylaminofluorene/partial hepatectomy rat is attenuated by short interfering RNA targeted to stromal cell-derived factor-1.
The American journal of pathology.
169(6):2066-74
[PMID] 17148669.
2005
Evidence regarding a stem cell origin of hepatocellular carcinoma.
Stem cell reviews.
1(3):261-4
[PMID] 17142863.
2005
Monocrotaline, an alternative to retrorsine-based hepatocyte transplantation in rodents.
Cell transplantation.
14(1):41-7
[PMID] 15789661.
2005
Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats.
Gastroenterology.
128(7):2077-88
[PMID] 15940639.
2005
Stem-cell therapy for hepatobiliary pancreatic disease.
Journal of hepato-biliary-pancreatic surgery.
12(3):190-5
[PMID] 15995806.
2005
Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells.
The American journal of pathology.
166(6):1781-91
[PMID] 15920163.
2004
Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes.
Laboratory investigation; a journal of technical methods and pathology.
84(5):607-17
[PMID] 15034596.
2004
Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice.
Hepatology (Baltimore, Md.).
40(4):918-24
[PMID] 15382177.
2004
Signalling in stem cells: meeting on signal transduction determining the fate of stem cells.
EMBO reports.
5(3):241-4
[PMID] 14978509.
2003
An overview of stem cell research and regulatory issues.
Mayo Clinic proceedings.
78(8):993-1003
[PMID] 12911047.
2003
ATP binding cassette transporter gene expression in rat liver progenitor cells.
Gut.
52(7):1060-7
[PMID] 12801967.
2003
Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers.
Hepatology (Baltimore, Md.).
37(3):632-40
[PMID] 12601361.
2003
Neural trans-differentiation potential of hepatic oval cells in the neonatal mouse brain.
Experimental neurology.
182(2):373-82
[PMID] 12895448.
2002
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Nature.
416(6880):542-5
[PMID] 11932747.
2002
Hepatic oval ‘stem’ cell in liver regeneration.
Seminars in cell & developmental biology.
13(6):405-9
[PMID] 12468240.
2002
Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury.
Journal of hematotherapy & stem cell research.
11(4):643-9
[PMID] 12201952.
2002
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
Proceedings of the National Academy of Sciences of the United States of America.
99(12):8078-83
[PMID] 12048252.
2002
SDF-1alpha/CXCR4: a mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats.
Cloning and stem cells.
4(4):339-51
[PMID] 12626097.
2001
Hepatic “stem” cells: coming full circle.
Blood cells, molecules & diseases.
27(3):590-600
[PMID] 11482872.
2001
Stem cells: a journey into a new frontier.
Journal of the American Society of Nephrology : JASN.
12(8):1773-1780
[DOI] 10.1681/ASN.V1281773.
[PMID] 11461953.
1999
Bone marrow as a potential source of hepatic oval cells.
Science (New York, N.Y.).
284(5417):1168-70
[PMID] 10325227.
1999
Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat.
Cancer research.
59(16):3954-60
[PMID] 10463591.
1999
Hepatocyte growth factor (HGF) and receptor (c-met) in normal and malignant astrocytic cells.
Anticancer research.
19(3A):1635-40
[PMID] 10470094.
1998
Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats.
Hepatology (Baltimore, Md.).
27(4):1030-8
[PMID] 9537443.
1998
Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat.
Hepatology (Baltimore, Md.).
27(2):433-45
[PMID] 9462642.
1997
Bile ductular damage induced by methylene dianiline inhibits oval cell activation.
The American journal of pathology.
151(4):905-9
[PMID] 9327722.
1997
Expression of HGF and cMet in the developing and adult brain.
Brain research. Developmental brain research.
102(2):299-303
[PMID] 9352114.
1997
Extracellular matrix remodeling at the early stages of liver regeneration in the rat.
Hepatology (Baltimore, Md.).
26(4):896-904
[PMID] 9328311.
1996
Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c-met receptor expression.
Stem cells (Dayton, Ohio).
14(5):592-602
[PMID] 8888500.
Grants
Sep 2018
– Aug 2021
The CTGF as a Therapeutic Target in Alcohol Liver Fibrosis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAAA
Jul 2012
– May 2016
Mechanisms of Oval Cell Activation and Differentiation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Contact Details
Phones:
- Business:
- (352) 294-5680
Emails:
- Business:
- bryonpetersen@peds.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100296
GAINESVILLE FL 32610 - Business Street:
-
DEPT OF PEDIATRICS
GAINESVILLE FL 32610