Oleksandr Kondratov,
Research Assistant Professor
Department:
MD-PEDS-CELL / MOLEC THERP DIV
Business Phone:
(352) 273-8150
Business Email:
o.g.kondratov@ufl.edu
Research Profile
Areas of Interest
- Adeno-Associated Viral Gene Therapy
- Cancer Genetics
- Cancer epigenetics
Open Researcher and Contributor ID (ORCID)
0000-0001-8305-2989
Publications
2024
Biodistribution and safety of a single rAAV3B-AAT vector for silencing and replacement of alpha-1 antitrypsin in Cynomolgus macaques.
Molecular therapy. Methods & clinical development.
32(1)
[DOI] 10.1016/j.omtm.2024.101200.
[PMID] 38445045.
2024
Suspension Culture Production and Purification of Adeno-Associated Virus by Iodixanol Density Gradient Centrifugation for In Vivo Applications.
Journal of visualized experiments : JoVE.
(204)
[DOI] 10.3791/66460.
[PMID] 38407338.
2023
Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion.
Human gene therapy.
34(7-8):289-302
[DOI] 10.1089/hum.2022.176.
[PMID] 36950804.
2023
Exploring the Comprehensive Kozak Sequence Landscape for AAV Production in Sf9 System
Viruses.
15(10)
[DOI] 10.3390/v15101983.
[PMID] 37896760.
2023
Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion.
Molecular therapy : the journal of the American Society of Gene Therapy.
31(12):3441-3456
[DOI] 10.1016/j.ymthe.2023.10.001.
[PMID] 37814449.
2021
A comprehensive study of a 29-capsid AAV library in a non-human primate central nervous system.
Molecular therapy : the journal of the American Society of Gene Therapy.
29(9):2806-2820
[DOI] 10.1016/j.ymthe.2021.07.010.
[PMID] 34298128.
2021
Applying machine learning to predict viral assembly for adeno-associated virus capsid libraries.
Molecular therapy. Methods & clinical development.
20:276-286
[DOI] 10.1016/j.omtm.2020.11.017.
[PMID] 33511242.
2020
Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity.
Molecular therapy. Methods & clinical development.
19:347-361
[DOI] 10.1016/j.omtm.2020.09.019.
[PMID] 33145371.
2019
Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System.
Molecular therapy. Methods & clinical development.
13:279-289
[DOI] 10.1016/j.omtm.2019.02.003.
[PMID] 30886878.
2019
Removal of Endotoxin from rAAV Samples Using a Simple Detergent-Based Protocol.
Molecular therapy. Methods & clinical development.
15:112-119
[DOI] 10.1016/j.omtm.2019.08.013.
[PMID] 31649960.
2017
Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells.
Molecular therapy : the journal of the American Society of Gene Therapy.
25(12):2661-2675
[DOI] 10.1016/j.ymthe.2017.08.003.
[PMID] 28890324.
2015
Aberrant expression of selenium-containing glutathione peroxidases in clear cell renal cell carcinomas.
Experimental oncology.
37(2):105-10
[PMID] 26112936.
2012
Alterations of the WNT7A gene in clear cell renal cell carcinomas.
PloS one.
7(10)
[DOI] 10.1371/journal.pone.0047012.
[PMID] 23056560.
2012
Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas.
Molecular medicine reports.
5(2):509-12
[DOI] 10.3892/mmr.2011.681.
[PMID] 22101383.
2012
The TCF4/β-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer.
Epigenetics.
7(8):930-9
[DOI] 10.4161/epi.21199.
[PMID] 22805760.
2011
Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors.
Cell adhesion & migration.
5(5):395-401
[DOI] 10.4161/cam.5.5.17949.
[PMID] 21975548.
2008
Hypermethylation of the 5’CpG island of the FHIT gene in clear cell renal carcinomas.
Cancer letters.
265(2):250-7
[DOI] 10.1016/j.canlet.2008.02.036.
[PMID] 18378390.
Contact Details
Phones:
- Business:
- (352) 273-8150
Emails:
- Business:
- o.g.kondratov@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100296
GAINESVILLE FL 32610 - Business Street:
-
2033 MOWRY RD RM 430G
GAINESVILLE FL 32610