Michael McIntosh, PhD

Division

Child Health Research Institute

Academic Title

Associate Professor, Pediatrics and Molecular Genetics & Microbiology

Contact Information

Phone: (352) 294-8870
mmcintosh@peds.ufl.edu

Office

Academic Research Building, Room R1-102

Lab

Academic Research Building, Room R1-156

Training

  • Postdoctoral Fellow, Thomas Jefferson University & Drexel Medical College
  • Ph.D., Drexel Medical College
  • B.S., The Pennsylvania State University

Research Overview

Advanced molecular biology and bioinformatics are combined with traditional microbiology to reveal connections between infectious agents and diseases of unknown etiology or emerging epidemiology. Lab emphasis is on detection and characterization of potential pathogens and investigating host microbial interactions to reveal underlying mechanisms of disease as well as targets for diagnosis or intervention.  Broad areas of study include microbial, in particular viral, discovery in the context of clinical disease, at the human animal/vector interface, and in the contexts of immunocompromise or cancer.

About

Michael McIntosh began his infectious disease career in herpes virology at Thomas Jefferson University.  He later earned a Ph.D. in Molecular Biology and Biotechnology in 1995 at the Medical College of Pennsylvania & Hahnemann University (now Drexel Medical College) where he investigated the unique biology of mitochondria in the malaria parasite.  He did postdoctoral fellowships in human polyomavirus JC research at Thomas Jefferson University and in malaria research at Drexel Medical College before joining the faculty at Yale University to investigate mechanisms of endocytosis by the malaria parasite.  In 2004, he joined the USDA National Veterinary Services Laboratories’ Foreign Animal Disease Diagnostic Laboratory (FADDL) on Plum Island where he served as a member of FADDL’s emergency Diagnostic Team, Head of the Proficiency and Validation Services Section, Head of Bioforensics, and most recently as Science Liaison.

Much of Dr. McIntosh’s scientific career has focused on diagnosis of emerging and foreign animal diseases, development and validation of new diagnostic tests, and development and use of cutting-edge molecular approaches to infectious disease diagnostics. His laboratory’s development of advanced molecular methods for virus detection, including panviral microarrays and next-generation sequencing have led to impactful examples of disease detection and response on national and international scales, most notably, the discovery of domestic swine as a host for Ebola.

 

Key Publications

Additional publications can be found in PubMed.

  1. Das A, Deng MY, Babiuk S, McIntosh MT. Modification of two capripoxvirus quantitative real-time PCR assays to improve diagnostic sensitivity and include beta-actin as an internal positive control. Journal of Veterinary Diagnostic Investigation 2017; 29(3):351-356.
  2. Barrette RW, Rowland JM, Grau FR, McIntosh MT. Development of a feature and template-assisted assembler and application to the analysis of a foot-and-mouth disease virus genotyping microarray. PLoS One. 2017; 12(1):e0166870.
  3. Wilson WC, Daniels P, Ostlund EN, Johnson DE, Oberst RD, Hairgrove TB, Mediger J, McIntosh MT. Diagnostic tools for bluetongue and epizootic hemorrhagic disease vruses applicable to North American veterinary diagnosticians. Vector Borne and Zoonotic Diseases 2015; 15(6):364-73.
  4. Barrette RW, Xu L, Rowland JM, McIntosh MT. Current perspectives on the phylogeny of Filoviridae. Infection, genetics and evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 2011; 11(7):1514-9.
  5. Barrette RW, Metwally SA, Rowland JM, Xu L, Zaki SR, Nichol ST, Rollin PE, Towner JS, Shieh WJ, Batten B, Sealy TK, Carrillo C, Moran KE, Bracht AJ, Mayr GA, Sirios-Cruz M, Catbagan DP, Lautner EA, Ksiazek TG, White WR, McIntosh MT. Discovery of swine as a host for the Reston ebolavirus. Science. 2009; 325(5937):204-6.
  6. Elliott DA, McIntosh MT, Hosgood HD 3rd, Chen S, Zhang G, Baevova P, Joiner KA. Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(7):2463-8.
  7. McIntosh MT, Behan SC, Mohamed FM, Lu Z, Moran KE, Burrage TG, Neilan JG, Ward GB, Botti G, Capucci L, Metwally SA. A pandemic strain of calicivirus threatens rabbit industries in the Americas. Virology Journal. 2007; 4:96.
  8. McIntosh MT, Vaid A, Hosgood HD, Vijay J, Bhattacharya A, Sahani MH, Baevova P, Joiner KA, Sharma P. Traffic to the malaria parasite food vacuole: a novel pathway involving a phosphatidylinositol 3-phosphate-binding protein. The Journal of Biological Chemistry. 2007; 282(15):11499-508.