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Frederick Kweh, Ph.D.

Division

Genetics and Metabolism

Academic Title

Postdoctoral Research Associate

Contact Information

Email: mayeck@ufl.edu

Training

  • Ph.D. in Biomedical Sciences, Genetics, August 2012, University of Florida, Gainesville, FL
  • Bachelor of Science, Microbiology, December 2004, University of Florida, Gainesville, FL

Research Overview

The focus of Dr. Kweh’s research is study the causes and consequences of obesity and hyperphagia in Prader-Willi syndrome (PWS).  This involves screening for mutations, metabolomics and analysis of serum, plasma, and brain tissue samples from PWS patients, non-PWS individuals with early-onset morbid obesity, and normal control subjects.  Dr. Kweh applies state-of-the-art techniques such as ELISA, LUMINEX, qRT-PCR, DNA sequencing, mass spectrometry, immunohistochemistry, high performance liquid chromatography, western blot, as well as standard molecular biology techniques.

Publications

  1. Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells.Li H, Zhang X, Fishbein L, Kweh F, Campbell-Thompson M, Perrin GQ, Muir D, Wallace M. Cancer Biol Ther. 2010 Oct 15;10(8):758-64. Epub 2010 Oct 15.
  2. Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG. Mol Carcinog. 2009 Nov;48(11):1005-17.
  3. Focal adhesion kinase and cancer. Golubovskaya VM, Kweh FA, Cance WG. Histol Histopathol. 2009 Apr;24(4):503-10. Review.
  4. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D, Cance WG. J Med Chem. 2008 Dec 11;51(23):7405-16.
  5. p53 regulates FAK expression in human tumor cells. Golubovskaya VM, Finch R, Kweh F, Massoll NA, Campbell-Thompson M, Wallace MR, Cance WG. Mol Carcinog. 2008 May;47(5):373-82.