Frederick Kweh, Ph.D.
Postdoctoral Research Associate
- Ph.D. in Biomedical Sciences, Genetics, August 2012, University of Florida, Gainesville, FL
- Bachelor of Science, Microbiology, December 2004, University of Florida, Gainesville, FL
The focus of Dr. Kweh’s research is study the causes and consequences of obesity and hyperphagia in Prader-Willi syndrome (PWS). This involves screening for mutations, metabolomics and analysis of serum, plasma, and brain tissue samples from PWS patients, non-PWS individuals with early-onset morbid obesity, and normal control subjects. Dr. Kweh applies state-of-the-art techniques such as ELISA, LUMINEX, qRT-PCR, DNA sequencing, mass spectrometry, immunohistochemistry, high performance liquid chromatography, western blot, as well as standard molecular biology techniques.
- Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells.Li H, Zhang X, Fishbein L, Kweh F, Campbell-Thompson M, Perrin GQ, Muir D, Wallace M. Cancer Biol Ther. 2010 Oct 15;10(8):758-64. Epub 2010 Oct 15.
- Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG. Mol Carcinog. 2009 Nov;48(11):1005-17.
- Focal adhesion kinase and cancer. Golubovskaya VM, Kweh FA, Cance WG. Histol Histopathol. 2009 Apr;24(4):503-10. Review.
- A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D, Cance WG. J Med Chem. 2008 Dec 11;51(23):7405-16.
- p53 regulates FAK expression in human tumor cells. Golubovskaya VM, Finch R, Kweh F, Massoll NA, Campbell-Thompson M, Wallace MR, Cance WG. Mol Carcinog. 2008 May;47(5):373-82.